Amping up the immune system’s T cells to improve their cancer-killing prowess

Combining immuno-oncology treatments like checkpoint inhibitors with other cancer-killing drugs is considered to be a key strategy for improving the response rate to immunotherapy. Now, a team of Canadian researchers is suggesting a new combination strategy for improving the response of the immune system’s T cells to immuno-oncology drugs, and it involves epigenetics.

Breaking Big Pharma’s AI barrier: Insilico Medicine uncovers novel target, new drug for pulmonary fibrosis in 18 months

For years, artificial intelligence has promised to shave months, if not years, off the total amount of time needed to develop a brand-new drug—and for potentially millions of dollars less, to boot. But by exactly how much has typically been left up to the imagination, though perhaps coming into clearer focus with each occasional breakthrough.

A safer Alzheimer’s drug than Biogen’s aducanumab? Denali-WashU drug shows better profile in mice

In 2018, a research group led by David Holtzman, M.D., at Washington University in St. Louis developed an antibody drug in collaboration with Denali Therapeutics that showed promise as a potential Alzheimer’s disease therapy. Now, the team has returned with mouse data suggesting the drug prospect might be a safer option than Biogen’s much-hyped aducanumab.

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