Fending off heart disease by blocking how immune cells ‘smell’ their surroundings

The buildup of fatty substances on the artery walls, known as atherosclerosis, involves inflammatory processes and can cause various cardiovascular diseases. Now, scientists at the La Jolla Institute for Immunology (LJI) have shed light on how targeting garbage-cleaning immune cells called macrophages might reverse or prevent the clogging problem.

FDA approval, global partnership on the agenda at Mithra as phase 3 menopause trials hit goals—with one blemish

Mithra has brushed off a missed co-primary endpoint in one of its two phase 3 clinical trials and given a bullish update (PDF) on the menopause drug, which it expects to gain a global partner this year and go on to win approval on both sides of the Atlantic in 2024. Shares in the Belgian biotech rose 9% to around 22 euros ($25).

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