New insights into how cancer cripples immune cells could fuel fresh I-O approaches

Manipulating the immune system’s T cells so they’re better able to recognize and kill cancer is the backbone of many immuno-oncology developments in recent years, but the treatments are far from perfect and they don’t work in every patient. In an effort to understand why, scientists at Brigham and Women’s Hospital and the Massachusetts Institute of Technology used high-power microscopy to watch breast cancer cells and T cells interact—and they made a discovery that could enhance immuno-oncology treatments.

Personalized T cells could offer an immunotherapy option to children with brain tumors

Medulloblastoma is a common brain tumor in children that becomes particularly tough to treat once it spreads. In an effort to find an immunotherapy that might offer hope to these young patients, scientists at Children’s National Hospital in Washington, D.C., used a specific type of DNA analysis to devise a novel therapy that’s showing promise in preclinical studies.

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