Could immuno-oncology treatments get a boost from a 64-year-old antipsychotic?

Prochlorperazine (PCZ) was first approved by the FDA back in 1956 to treat psychosis, and, even though it’s been overtaken by newer antipsychotics, it’s still prescribed today to relieve nausea and vomiting. Now, Australian researchers are suggesting a new use for the drug: to improve the effectiveness of checkpoint inhibitors and other antibodies in cancer.

Insights into how Novo Nordisk’s Saxenda cuts food cravings may inspire new obesity drugs

Novo Nordisk’s obesity drug Saxenda, which shares the ingredient liraglutide with the company’s diabetes treatment Victoza, has been shown to reduce appetite. The drug is an analog of naturally occurring GLP-1, a hormone that’s released after food intake to create the sensation of fullness. But the exact neuronal sites the drug affects remain largely unknown.

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